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Yale Gets $2.4M for Stem-Cell Research
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Business New Haven
6/24/2002
By: BNH
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NEW HAVEN - Yale has received a $2.4 million grant from the National Institute of Neurological Disorders and Stroke for stem-cell research related to Parkinson's Disease.
The researchers will investigate whether human neural stem cells can cure experimental Parkinson's disease in monkeys. A selective neurotoxin, MPTP, destroys dopamine cells, causing the muscle rigidity, lack of coordination, difficulty moving and tremors that are characteristic of the disease.
The lead investigator is D. Eugene Redmond, professor of psychiatry and neurosurgery at Yale School of Medicine.
The project will test whether human neural stem cells will survive, differentiate and integrate in the brain of normal adult monkeys without immunological rejection or harmful overgrowth, and whether they eliminate MPTP-induced parkinsonism and are distributed to areas where the dopamine neurons are injured.
The project will be carried out in collaboration with scientists from Harvard Medical School, the University of Colorado and the St. Kitts Biomedical Research Foundation.
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