|
|
|
Study: Drug May Kill Cancer Cells
|
Business New Haven
3/1/2004
By: BNH
|
In a new study, Yale researchers have reported preliminary results that show an experimental anti-cancer drug called phenoxodiol may help kill cancer cells and increase the effectiveness of standard chemotherapy.
Researchers administered the drug to female patients at Yale New-Haven Hospital with recurrent ovarian cancers, many of which were unresponsive to chemotherapy. The main goal of the study was to determine the toxicity of phenoxodiol, and to decide the proper dosage of the drug to give to patients, in conjunction with other chemotherapy drugs.
"We used four different concentrations of [phenoxodiol], and we didn't find any toxicity," said Gil Mor MD, Ph,D, Yale School of Medicine associate professor of obstetrics and gynecology.
The drug also resulted in significant disease stabilization when administered twice a week as a monotherapy.
While phenoxodiol has been shown to stop ovarian cancer in animals on its own, the drug is being developed as a chemo-sensitizer, meant to increase the sensitivity of cancer cells to chemotherapy drugs. It will be used in conjunction with chemotherapy.
The drug is currently being tested on other cancer types, including treatment of cervical and vaginal cancers.
Principal investigator on the study is Thomas Rutherford, M.D., associate professor of gynecology at the Yale School of Medicine.
|
Go FirstGo PreviousGo
NextGo LastGo
to Index
|
|
