Ultomiris Box EnglishNews and Analysis

By Mitchell Young

BOSTON, NEW HAVEN: With an Investors Business Daily headline “Santa Comes Early As This Biotech Stock Grabs its Fourth Approval” the company could typically expect a rising stock price. Instead investors in Alexion Pharmaceuticals [NYSE: Alxn] have seemingly abandoned the company in spite of a slew of “good news” in the past few months.

The stock market and general biotech slide certainly accounts for some of the stock’s troubles, but the decline to a 52 week low at $92.56 on December 24 came in the face of numerous analyst’s “buy” recommendations. Indeed analyst predictions are listed for a “consensus”  $165 share price. In March 2018 with the stock closing at $122 per share, a Deutsch Bank analyst in reaction to positive clinical data, calling it a “clear success” suggested a buy recommendation with a $160 per share target. As recently as September on the back of more positive clinical results for a new disease treatment, several analysts reiterated and raised their support for the company, with expected share prices of $140 to $170 per share.

vab melintaNEW HAVEN: Melinta Therapeutics, Inc. [Nasdaq: MLNT] and the $3.5 billion Menarini Group, based in Florence, Italy have entered into an agreement where Menarini will acquire the exclusive rights to co-develop and commercialize three antibiotics developed by Melinta, Vabomere™, Orbactiv® and Minocin® for Injection in 68 countries in Europe, Asia-Pacific including China, South Korea, and Australia (Japan excluded), and the Commonwealth of Independent States (CIS) including Russia for a total consideration of up to $265 million.

Under the terms of the agreement, Melinta will receive an undisclosed upfront licensing fee, additional approval and sales-based milestone payments, and potential royalty payments based on a percentage of net sales of the three products.

Arvinas' CEO Houston puts nearly half a million dollars on the line in newly public company.

NEW HAVEN: A city biotech based on technology of Yale researcher Craig Crews has taken to the public markets with an Initial Public Offering on September 27.

Arvinas, Inc. [Nasdaq: ARVN], the company’s CEO, Chairman and other key executives have made significant stock purchases in the open market.

Arvinas went public on September 27 at $16 per share, prices for the stock spiked as high as $21 nearly immediately. The stock however tracked back down and was trading under its offering price on October 8.

peter milliganNEW HAVEN: Melinta Therapeutics, Inc. [Nasdaq:MLNT], a commercial-stage company, developing commercializing novel antibiotics to treat serious bacterial infections, has appointed Peter Milligan as its new Chief Financial Officer, effective immediately. He will succeed current CFO Paul Estrem, who is retiring from Melinta on October 1.

A Melinta release says “Milligan is an accomplished executive and established corporate leader who brings nearly 30 years of financial leadership experience, with extensive experience in managing all aspects of corporate and operational financial matters, including numerous capital market transactions.”

Screen Shot 2018 06 20 at 11.30.00 AMNEW HAVEN: Biohaven Pharmaceutical Holding Company Ltd. [NYSE: BHVN] based in the city’s downtown has just shown the wisdom of its licensing and developing programs.

Royalty Pharma a New York based bioscience investment firm has agreed to purchase a tiered, sales-based participation rights on future global net sales of products containing rimegepant, the company’s migraine treatment in development.

Royalty Pharma will pay $100 million for the rights and has also agreed to purchase $50 million in common shares of Biohaven, at a price of $45.00 per share. The purchase price, represents an approximately 19% premium over the 15-day volume-weighted average price through June 15, 2018.

Screen Shot 2018 06 19 at 10.40.15 AMBy Mitchell Young

NEW HAVEN, AMSTERDAM: Alexion Pharmaceuticals, Inc. [NYSE: ALXN] has taken another, albeit small step to extend its drug portfolio. The company has made an investment and development partnership with Complement Pharma an Amsterdam NV start up [founded in 2017] biotech company focusing on “complement inhibition to modify neurodegenerative disease progression.”

Under the terms of the agreement, Alexion will provide Complement Pharma with up to $16 million in milestone-dependent payments through Phase 1b development. While the current investment is modest, Alexion has also negotiated the ability to outright purchase CP during the term of the agreement.

Vlad CoricNEW HAVEN: Vlad Coric CEO of Biohaven Pharmaceutical Holding Company Ltd. [NYSE:BHVN], based in downtown New Haven has been by Ernst & Young as its Entrepreneur Of The Year 2018 Award Winner in New York Region for the Health Care Category.

EY’s awards program “recognizes entrepreneurs who are excelling in areas such as innovation, financial performance and personal commitment to their businesses and communities. Dr. Coric was selected as an award winner by a panel of independent judges.”

With the regional award Coric is eligible for the national competition, announced in November.